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Cardiomyopathy, Hypertrophic obstructive

DOID EFO MESH SNOMED PheWeb

I9_CARDMYOHYP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I42.1
Hospital discharge: ICD-9 4251A
Hospital discharge: ICD-8 42500
Cause of death: ICD-10 I42.1
Cause of death: ICD-9 4251A
Cause of death: ICD-8 42500

2 out of 7 registries used, show all original rules.

537

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Check minimum number of events None

537

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Include endpoints None

537

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Remove individuals based on genotype QC

519

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I9_CARDMYOHYP

Control definitions

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5
Parent code in ICD-10 I42
Name in latin Cardiomyopathia hypertrophica obstructiva

Summary Statistics

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Key figures

All Female Male
Number of individuals 519 204 315
Unadjusted prevalence (%) 0.14 0.10 0.19
Mean age at first event (years) 55.44 53.81 56.50

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.66 [1.23, 5.75] 1.3e-2 101
15 years 0.01 1.56 [0.85, 2.87] 1.5e-1 38
5 years 0.00 4.11 [2.37, 7.11] 4.4e-7 30
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive
GWS hits: 16

Survival analyses between endpoints

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Plot

before Cardiomyopathy, Hypertrophic obstructive
after Cardiomyopathy, Hypertrophic obstructive

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cardiomyopathy, Hypertrophic obstructive

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Endpoint not on priority list, no data to show.