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Proliferative diabetic retinopathy

DOID EFO MESH SNOMED PheWeb

H7_RETINOPATHYDIAB_PROLIF

proliferative diabetic retinopathy: Later stage of diabetic retinopathy, characterized by neovascularisation of the retina

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H36.03*
Cause of death: ICD-10 H36.03*

2 out of 7 registries used, show all original rules.

2533

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Check minimum number of events None

2533

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Include endpoints None

2533

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Remove individuals based on genotype QC

2468

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H7_RETINOPATHYDIAB_PROLIF

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 2468 1088 1380
Unadjusted prevalence (%) 0.65 0.52 0.83
Mean age at first event (years) 47.13 44.65 49.08

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.12 9.03 [7.11, 11.46] 3.5e-73 438
15 years 0.03 5.25 [4.09, 6.75] 2.4e-38 222
5 years 0.01 7.84 [6.10, 10.09] 6.2e-58 130
1 year 0.00 6.33 [3.94, 10.18] 2.5e-14 21

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETINOPATHYDIAB_PROLIF – Proliferative diabetic retinopathy
GWS hits: 4

Survival analyses between endpoints

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Plot

before Proliferative diabetic retinopathy
after Proliferative diabetic retinopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Proliferative diabetic retinopathy

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