Proliferative diabetic retinopathy

DM_RETINA_PROLIF

proliferative diabetic retinopathy: Later stage of diabetic retinopathy, characterized by neovascularisation of the retina

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H36.03*

Hospital discharge: ICD-9 3620B

Cause of death: ICD-10 H36.03*

Cause of death: ICD-9 3620B

Operations: NOMESCO codes ^CKC10|^CKC15|^CKC12|^CKC50

3 out of 7 registries used, show all original rules.

9120

Check minimum number of events None

9120

Include endpoints

DM_RETINA_PROLIF_NOS_ET_OPER

9811

Remove individuals based on genotype QC

9511

DM_RETINA_PROLIF

Control definitions

Control exclude DM_RETINOPATHY

Extra metadata

First used in FinnGen datafreeze DF2

NAME	DM_RETINA_PROLIF
CONTROL_EXCLUDE	DM_RETINOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	DM_RETINA_PROLIF_NOS_ET_OPER
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H3603
HD_ICD_9	3620B
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H3603
COD_ICD_9	3620B
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM	^CKC10\|^CKC15\|^CKC12\|^CKC50
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Proliferative diabetic retinopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	9511	4560	4951
Unadjusted prevalence (%)	2.52	2.16	2.98
Mean age at first event (years)	55.77	54.49	56.95

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.15 [2.47, 4.02]	2.7e-20	1231
15 years	0.01	2.14 [1.76, 2.59]	9.5e-15	628
5 years	0.00	3.14 [2.67, 3.71]	1.6e-42	329
1 year	0.00	4.04 [3.12, 5.23]	3.0e-26	83

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_RETINA_PROLIF – Proliferative diabetic retinopathy
GWS hits: 4

Survival analyses between endpoints

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Plot

before Proliferative diabetic retinopathy
after Proliferative diabetic retinopathy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Proliferative diabetic retinopathy

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Endpoint not on priority list, no data to show.

≡ Risteys

R9

R8

R7

R6

R5

R4

R3