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Disorders of ocular muscles, binocular movement, accommodation and refraction

DOID EFO MESH PheWeb

H7_OCUMUSCLE

trochlear nerve disease: Diseases of the fourth cranial (trochlear) nerve or its nucleus in the midbrain. The nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit. Clinical manifestations include weakness of the superior oblique muscle which causes vertical DIPLOPIA that is maximal when the affected eye is adducted and directed inferiorly. Head tilt may be seen as a compensatory mechanism for diplopia and rotation of the visual axis. Common etiologies include CRANIOCEREBRAL TRAUMA and INFRATENTORIAL NEOPLASMS.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H49-H52
Cause of death: ICD-10 H49-H52

2 out of 7 registries used, show all original rules.

13542

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Check minimum number of events None

13542

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Include endpoints

16688

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Remove individuals based on genotype QC

16040

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H7_OCUMUSCLE

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 16040 10183 5857
Unadjusted prevalence (%) 4.25 4.83 3.52
Mean age at first event (years) 38.82 36.59 42.70

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.93 [1.55, 2.39] 2.7e-9 879
15 years 0.01 1.29 [1.05, 1.57] 1.4e-2 393
5 years 0.00 2.17 [1.76, 2.69] 6.0e-13 205
1 year 0.00 6.23 [4.83, 8.05] 1.1e-44 112

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_OCUMUSCLE – Disorders of ocular muscles, binocular movement, accommodation and refraction
GWS hits: 2

Survival analyses between endpoints

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Plot

before Disorders of ocular muscles, binocular movement, accommodation and refraction
after Disorders of ocular muscles, binocular movement, accommodation and refraction

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Disorders of ocular muscles, binocular movement, accommodation and refraction

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Endpoint not on priority list, no data to show.