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Epilepsy

DOID EFO MESH SNOMED PheWeb

G6_EPLEPSY

epilepsy: A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G40
Hospital discharge: ICD-9 345
Hospital discharge: ICD-8 345
Hospital discharge: excluded ICD-9 3452|3453
Hospital discharge: excluded ICD-8 34520
Cause of death: ICD-10 G40
Cause of death: ICD-9 345
Cause of death: ICD-8 345
Cause of death: excluded ICD-9 3452|3453
Cause of death: excluded ICD-8 34520
KELA reimbursements: KELA codes 111

3 out of 7 registries used, show all original rules.

12149

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Check minimum number of events None

12149

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Include endpoints None

12149

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Remove individuals based on genotype QC

11740

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G6_EPLEPSY

Control definitions

Control exclude G6_EPIPAROX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47

Summary Statistics

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Key figures

All Female Male
Number of individuals 11740 5741 5999
Unadjusted prevalence (%) 3.11 2.72 3.61
Mean age at first event (years) 42.99 38.70 47.09

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.08 [3.32, 5.02] 7.6e-41 2343
15 years 0.01 1.94 [1.66, 2.28] 3.0e-16 756
5 years 0.01 4.86 [4.25, 5.56] <1e-100 673
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_EPLEPSY – Epilepsy
GWS hits:

Survival analyses between endpoints

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Plot

before Epilepsy
after Epilepsy

loading spinner Loading survival analyses plot