Generalized epilepsy, mode (most common among epilepsy diagnosis)

DOID EFO MESH SNOMED PheWeb

GE_MODE

generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Check mode of ICD-10 codes: %345[0-1], %G40[0-1]

Hospital Discharge: ICD-10 G40.0, G40.1

Hospital discharge: ICD-9 %345[0-1]

Hospital discharge: ICD-8 %345[0-1]

Hospital discharge: excluded ICD-8 34511

Cause of death: ICD-10 G40.0, G40.1

Cause of death: ICD-9 %345[0-1]

Cause of death: ICD-8 %345[0-1]

Cause of death: excluded ICD-8 34511

2 out of 7 registries used, show all original rules.

2320

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Check minimum number of events None

2320

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Include endpoints None

2320

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Remove individuals based on genotype QC

2235

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GE_MODE

Control definitions

Control exclude G6_EPLEPSY

Extra metadata

First used in FinnGen datafreeze DF3

NAME	GE_MODE
CONTROL_EXCLUDE	G6_EPLEPSY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	%G40[0-1]
HD_ICD_9	%345[0-1]
HD_ICD_8	%345[0-1]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL	34511
COD_MAINONLY
COD_ICD_10	%G40[0-1]
COD_ICD_9	%345[0-1]
COD_ICD_8	%345[0-1]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL	34511
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Generalized epilepsy, mode (most common among epilepsy diagnosis) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2235	1147	1088
Unadjusted prevalence (%)	0.59	0.54	0.65
Mean age at first event (years)	42.07	38.16	46.19

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.93 [1.60, 5.38]	5.0e-4	404
15 years	0.01	1.51 [0.94, 2.43]	8.8e-2	119
5 years	0.01	4.53 [3.11, 6.58]	2.6e-15	116
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: GE_MODE – Generalized epilepsy, mode (most common among epilepsy diagnosis)
GWS hits:

Survival analyses between endpoints

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Plot

before Generalized epilepsy, mode (most common among epilepsy diagnosis)
after Generalized epilepsy, mode (most common among epilepsy diagnosis)

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Table

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Drugs most likely to be purchased after Generalized epilepsy, mode (most common among epilepsy diagnosis)

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Endpoint not on priority list, no data to show.