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Focal epilepsy, mode (most common among epilepsy diagnosis)

DOID EFO MESH SNOMED PheWeb

FE_MODE

partial epilepsy: A seizure caused by a localized disorder.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Check mode of ICD-10 codes: %3453, %345[4-5], %G403
Hospital Discharge: ICD-10 G40.3
Hospital discharge: ICD-9 %345[4-5]
Hospital discharge: ICD-8 %3453
Cause of death: ICD-10 G40.3
Cause of death: ICD-9 %345[4-5]
Cause of death: ICD-8 %3453

2 out of 7 registries used, show all original rules.

1300

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Check minimum number of events None

1300

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Include endpoints None

1300

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Remove individuals based on genotype QC

1260

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FE_MODE

Control definitions

Control exclude G6_EPLEPSY

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1260 736 524
Unadjusted prevalence (%) 0.33 0.35 0.32
Mean age at first event (years) 28.19 25.53 31.92

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.99 [2.18, 4.10] 1.0e-11 149
15 years 0.01 1.93 [1.44, 2.58] 9.4e-6 65
5 years 0.00 2.00 [1.32, 3.02] 1.0e-3 23
1 year 0.00 5.45 [3.01, 9.86] 2.2e-8 12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: FE_MODE – Focal epilepsy, mode (most common among epilepsy diagnosis)
GWS hits:

Survival analyses between endpoints

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Plot

before Focal epilepsy, mode (most common among epilepsy diagnosis)
after Focal epilepsy, mode (most common among epilepsy diagnosis)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Focal epilepsy, mode (most common among epilepsy diagnosis)

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Endpoint not on priority list, no data to show.