Focal epilepsy, mode (most common among epilepsy diagnosis)

FE_MODE

partial epilepsy: A seizure caused by a localized disorder.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Check mode of ICD-10 codes: %3453, %345[4-5], %G403
Hospital Discharge: ICD-10 G40.3
Hospital discharge: ICD-9 %345[4-5]
Hospital discharge: ICD-8 %3453
Cause of death: ICD-10 G40.3
Cause of death: ICD-9 %345[4-5]
Cause of death: ICD-8 %3453

2 out of 7 registries used, show all original rules.

1300

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Check minimum number of events None

1300

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Include endpoints None

1300

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Remove individuals based on genotype QC

1260

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FE_MODE

Control definitions

Control exclude G6_EPLEPSY

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 1260 736 524
Unadjusted prevalence (%) 0.33 0.35 0.32
Mean age at first event (years) 28.19 25.53 31.92

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.99 [2.18, 4.10] 1.0e-11 149
15 years 0.01 1.93 [1.44, 2.58] 9.4e-6 65
5 years 0.00 2.00 [1.32, 3.02] 1.0e-3 23
1 year 0.00 5.45 [3.01, 9.86] 2.2e-8 12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: FE_MODE – Focal epilepsy, mode (most common among epilepsy diagnosis)
GWS hits:

Survival analyses between endpoints

Plot

before Focal epilepsy, mode (most common among epilepsy diagnosis)
after Focal epilepsy, mode (most common among epilepsy diagnosis)

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Drugs most likely to be purchased after Focal epilepsy, mode (most common among epilepsy diagnosis)

Endpoint not on priority list, no data to show.