Disorders of parathyroid gland


hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E20, E21
Cause of death: ICD-10 E20, E21

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints


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Remove individuals based on genotype QC


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Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 6362 4683 1679
Unadjusted prevalence (%) 1.69 2.22 1.01
Mean age at first event (years) 62.37 62.07 63.19


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.90 [1.41, 2.55] 2.1e-5 1343
15 years 0.01 1.32 [1.03, 1.69] 2.8e-2 639
5 years 0.00 2.38 [1.99, 2.83] 4.0e-22 399
1 year 0.00 4.03 [3.22, 5.04] 1.7e-34 131

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_PARATHYRO – Disorders of parathyroid gland
GWS hits: 8

Survival analyses between endpoints


before Disorders of parathyroid gland
after Disorders of parathyroid gland

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Drugs most likely to be purchased after Disorders of parathyroid gland

Endpoint not on priority list, no data to show.