hyperparathyroidism: Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.

Endpoint definition

FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E21.09, E21.1, E21.2, E21.3
Hospital discharge: ICD-9 2520
Hospital discharge: ICD-8 2520
Cause of death: ICD-10 E21.09, E21.1, E21.2, E21.3
Cause of death: ICD-9 2520
Cause of death: ICD-8 2520
Medicine purchases: ATC H05B

3 out of 7 registries used, show all original rules.


diagram downward connector
diagram bullet

Check minimum number of events

Min. number of events 3


diagram downward connector

Include endpoints None


diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC


diagram downward connector

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 5590 4078 1512
Unadjusted prevalence (%) 1.48 1.93 0.91
Mean age at first event (years) 63.33 63.08 64.01


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.03 [1.54, 2.66] 3.5e-7 1264
15 years 0.01 1.38 [1.12, 1.69] 2.6e-3 613
5 years 0.00 2.46 [2.10, 2.89] 8.1e-29 375
1 year 0.00 3.94 [3.16, 4.91] 5.7e-34 116

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_HYPERPARA – Hyperparathyroidism
GWS hits: 9

Survival analyses between endpoints


before Hyperparathyroidism
after Hyperparathyroidism

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hyperparathyroidism

Endpoint not on priority list, no data to show.