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Hyperparathyroidism

DOID EFO MESH SNOMED PheWeb

E4_HYPERPARA

hyperparathyroidism: Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E21.09, E21.1, E21.2, E21.3
Hospital discharge: ICD-9 2520
Hospital discharge: ICD-8 2520
Cause of death: ICD-10 E21.09, E21.1, E21.2, E21.3
Cause of death: ICD-9 2520
Cause of death: ICD-8 2520
Medicine purchases: ATC H05B

3 out of 7 registries used, show all original rules.

5769

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Check minimum number of events

Min. number of events 3

5769

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Include endpoints None

5769

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Remove individuals based on genotype QC

5590

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E4_HYPERPARA

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 5590 4078 1512
Unadjusted prevalence (%) 1.48 1.93 0.91
Mean age at first event (years) 63.33 63.08 64.01

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.03 [1.54, 2.66] 3.5e-7 1264
15 years 0.01 1.38 [1.12, 1.69] 2.6e-3 613
5 years 0.00 2.46 [2.10, 2.89] 8.1e-29 375
1 year 0.00 3.94 [3.16, 4.91] 5.7e-34 116

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERPARA – Hyperparathyroidism
GWS hits: 9

Survival analyses between endpoints

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Plot

before Hyperparathyroidism
after Hyperparathyroidism

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hyperparathyroidism

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Endpoint not on priority list, no data to show.