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Hypoparathyroidism

DOID EFO MESH SNOMED PheWeb

E4_HYPOPARA

hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E20
Hospital discharge: ICD-9 2521
Hospital discharge: ICD-8 2521
Cause of death: ICD-10 E20
Cause of death: ICD-9 2521
Cause of death: ICD-8 2521
KELA reimbursements: KELA codes 106
Medicine purchases: ATC H05AA

4 out of 7 registries used, show all original rules.

921

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Check minimum number of events

Min. number of events 3

921

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Include endpoints None

921

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Remove individuals based on genotype QC

899

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E4_HYPOPARA

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hypoparathyreoidismus

Summary Statistics

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Key figures

All Female Male
Number of individuals 899 713 186
Unadjusted prevalence (%) 0.24 0.34 0.11
Mean age at first event (years) 55.80 55.69 56.18

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.16 [1.86, 5.36] 2.2e-5 102
15 years 0.01 1.45 [0.77, 2.73] 2.5e-1 35
5 years 0.00 2.94 [1.60, 5.41] 5.3e-4 31
1 year 0.00 7.31 [3.61, 14.81] 3.2e-8 16

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPOPARA – Hypoparathyroidism
GWS hits:

Survival analyses between endpoints

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Plot

before Hypoparathyroidism
after Hypoparathyroidism

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Drugs most likely to be purchased after Hypoparathyroidism

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Endpoint not on priority list, no data to show.