Unspecified diabetes with neurological complications

E4_DMNASNEU

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E12.4+, E13.4+, E14.4+
Hospital discharge: ICD-9 2505C|2505X
Cause of death: ICD-10 E12.4+, E13.4+, E14.4+
Cause of death: ICD-9 2505C|2505X

2 out of 7 registries used, show all original rules.

105

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Check minimum number of events None

105

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Include endpoints None

105

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Remove individuals based on genotype QC

104

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E4_DMNASNEU

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 104 30 74
Unadjusted prevalence (%) 0.03 0.01 0.04
Mean age at first event (years) 54.28 52.33 55.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_DMNASNEU – Unspecified diabetes with neurological complications
GWS hits:

Survival analyses between endpoints

Plot

before Unspecified diabetes with neurological complications
after Unspecified diabetes with neurological complications

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Drugs most likely to be purchased after Unspecified diabetes with neurological complications

Endpoint not on priority list, no data to show.