Seropositive rheumatoid arthritis, wide


rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M05
Hospital discharge: ICD-9 7140A|7141
Cause of death: ICD-10 M05
Cause of death: ICD-9 7140A|7141

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M05-M14
Name in latin Arthritis rheumatoides seropositiva

Summary Statistics

Key figures

All Female Male
Number of individuals 9243 6328 2915
Unadjusted prevalence (%) 2.45 3.00 1.75
Mean age at first event (years) 54.38 52.60 58.23


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.51 [2.08, 3.03] 9.3e-22 1224
15 years 0.01 1.67 [1.40, 1.99] 1.7e-8 600
5 years 0.00 2.35 [2.00, 2.76] 1.8e-25 270
1 year 0.00 3.42 [2.64, 4.43] 1.1e-20 74

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide
GWS hits: 27

Survival analyses between endpoints


before Seropositive rheumatoid arthritis, wide
after Seropositive rheumatoid arthritis, wide

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis, wide

Endpoint not on priority list, no data to show.