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Drug-induced osteoporosis with pathological fracture

MESH PheWeb

OSTPOPATFRACTURE

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M80.4#
Cause of death: ICD-10 M80.4#

2 out of 7 registries used, show all original rules.

361

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Check minimum number of events None

361

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Include endpoints None

361

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Remove individuals based on genotype QC

357

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OSTPOPATFRACTURE

Control definitions

Control exclude OSTEOPOROSIS_FRACTURE_FG

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 M80
Name in latin Osteoporosis e medicamento cum fractura pathologica

Summary Statistics

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Key figures

All Female Male
Number of individuals 357 255 102
Unadjusted prevalence (%) 0.09 0.12 0.06
Mean age at first event (years) 64.77 64.56 65.29

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.39 [0.50, 11.41] 2.7e-1 51
15 years 0.01 1.29 [0.29, 5.74] 7.4e-1 21
5 years 0.00 3.86 [1.40, 10.66] 9.0e-3 19
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: OSTPOPATFRACTURE – Drug-induced osteoporosis with pathological fracture
GWS hits:

Survival analyses between endpoints

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Plot

before Drug-induced osteoporosis with pathological fracture
after Drug-induced osteoporosis with pathological fracture

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Drug-induced osteoporosis with pathological fracture

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Endpoint not on priority list, no data to show.