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Osteoporosis

DOID EFO MESH SNOMED PheWeb

M13_OSTEOPOROSIS

osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M80, M81, M82*
Hospital discharge: ICD-9 733[0-1]
Hospital discharge: ICD-8 7230|72391
Cause of death: ICD-10 M80, M81, M82*
Cause of death: ICD-9 733[0-1]
Cause of death: ICD-8 7230|72391

2 out of 7 registries used, show all original rules.

7511

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Check minimum number of events None

7511

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Include endpoints None

7511

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Remove individuals based on genotype QC

7300

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M13_OSTEOPOROSIS

Control definitions

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Osteoporosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 7300 5538 1762
Unadjusted prevalence (%) 1.94 2.63 1.06
Mean age at first event (years) 67.27 67.81 65.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.99 [3.62, 6.88] 7.9e-23 1380
15 years 0.01 1.91 [1.53, 2.37] 5.3e-9 412
5 years 0.01 5.57 [4.77, 6.49] <1e-100 593
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEOPOROSIS – Osteoporosis
GWS hits: 7

Survival analyses between endpoints

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Plot

before Osteoporosis
after Osteoporosis

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