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Other disorders of bone

DOID EFO MESH SNOMED PheWeb

M13_OTHERBONE

secondary hypertrophic osteoarthropathy: Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M89, M90*, M90.6*C40.99, M90.6*C41.99, M91-M94
Cause of death: ICD-10 M89, M90*, M90.6*C40.99, M90.6*C41.99, M91-M94

2 out of 7 registries used, show all original rules.

4953

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Check minimum number of events None

4953

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Include endpoints

6799

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Remove individuals based on genotype QC

6568

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M13_OTHERBONE

Control definitions

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other disorders of bone based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 6568 3860 2708
Unadjusted prevalence (%) 1.74 1.83 1.63
Mean age at first event (years) 39.11 40.22 37.52

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.45 [1.03, 2.04] 3.2e-2 432
15 years 0.01 0.88 [0.65, 1.19] 4.1e-1 140
5 years 0.00 2.19 [1.64, 2.93] 9.2e-8 88
1 year 0.00 8.07 [5.87, 11.08] 4.6e-38 62

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OTHERBONE – Other disorders of bone
GWS hits:

Survival analyses between endpoints

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Plot

before Other disorders of bone
after Other disorders of bone

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Drugs most likely to be purchased after Other disorders of bone

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Endpoint not on priority list, no data to show.