Other specified/unspecified disorders of bone/cartilage

DOID EFO MESH SNOMED PheWeb

M13_BONEDISNAS

cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M89.80, M89.81, M89.88, M89.9, M94.8, M94.9

Hospital discharge: ICD-9 7339

Hospital discharge: ICD-8 7239[8-9]

Cause of death: ICD-10 M89.80, M89.81, M89.88, M89.9, M94.8, M94.9

Cause of death: ICD-9 7339

Cause of death: ICD-8 7239[8-9]

2 out of 7 registries used, show all original rules.

788

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Check minimum number of events None

788

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Include endpoints None

788

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Remove individuals based on genotype QC

769

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M13_BONEDISNAS

Control definitions

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

NAME	M13_BONEDISNAS
CONTROL_EXCLUDE	M13_OSTEOCHONDRO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M89[8-9]\|M94[8-9]
HD_ICD_9	7339
HD_ICD_8	7239[8-9]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M89[8-9]\|M94[8-9]
COD_ICD_9	7339
COD_ICD_8	7239[8-9]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Other specified/unspecified disorders of bone/cartilage based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	769	346	423
Unadjusted prevalence (%)	0.20	0.16	0.25
Mean age at first event (years)	36.61	41.12	32.92

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.84 [1.93, 4.17]	1.2e-7	73
15 years	0.01	1.32 [0.86, 2.01]	2.0e-1	22
5 years	0.00	2.47 [1.41, 4.31]	1.5e-3	13
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_BONEDISNAS – Other specified/unspecified disorders of bone/cartilage
GWS hits:

Survival analyses between endpoints

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Plot

before Other specified/unspecified disorders of bone/cartilage
after Other specified/unspecified disorders of bone/cartilage

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Table

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Drugs most likely to be purchased after Other specified/unspecified disorders of bone/cartilage

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Endpoint not on priority list, no data to show.