Disorders of muscles

M13_MUSCLE

myositis: An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M60-M63
Cause of death: ICD-10 M60-M63

2 out of 7 registries used, show all original rules.

2565

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Check minimum number of events None

2565

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Remove individuals based on genotype QC

3008

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M13_MUSCLE

Control definitions

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Disorders of muscles based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 3008 1599 1409
Unadjusted prevalence (%) 0.80 0.76 0.85
Mean age at first event (years) 49.74 48.07 51.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.53 [0.45, 5.24] 5.0e-1 286
15 years 0.01 1.09 [0.40, 2.93] 8.7e-1 108
5 years 0.00 2.76 [1.37, 5.57] 4.6e-3 74
1 year 0.00 10.75 [5.62, 20.55] 7.1e-13 54

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_MUSCLE – Disorders of muscles
GWS hits: 1

Survival analyses between endpoints

Plot

before Disorders of muscles
after Disorders of muscles

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Drugs most likely to be purchased after Disorders of muscles

Endpoint not on priority list, no data to show.