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Cholangitis (primary sclerosing, PSC), with reimbursement 202

DOID EFO MESH SNOMED PheWeb

K11_CHOLANGI_STRICT

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

K11_REIMB_202

21348

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K83.0
Hospital discharge: ICD-9 5761
Hospital discharge: ICD-8 5750[4-5]
Cause of death: ICD-10 K83.0
Cause of death: ICD-9 5761
Cause of death: ICD-8 5750[4-5]

2 out of 7 registries used, show all original rules.

482

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Check minimum number of events None

482

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Include endpoints None

482

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Remove individuals based on genotype QC

471

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K11_CHOLANGI_STRICT

Control definitions

Control exclude K11_IBD_STRICT_PSC
Control conditions not K11_REIMB_202

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 K83
Name in latin Cholangitis

Summary Statistics

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Key figures

All Female Male
Number of individuals 471 256 215
Unadjusted prevalence (%) 0.12 0.12 0.13
Mean age at first event (years) 44.40 46.67 41.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 7.60 [2.81, 20.57] 6.5e-5 29
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_CHOLANGI_STRICT – Cholangitis (primary sclerosing, PSC), with reimbursement 202
GWS hits: 1

Survival analyses between endpoints

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Plot

before Cholangitis (primary sclerosing, PSC), with reimbursement 202
after Cholangitis (primary sclerosing, PSC), with reimbursement 202

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cholangitis (primary sclerosing, PSC), with reimbursement 202

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Endpoint not on priority list, no data to show.