≡ Risteys
R9

Documentation Changelog GitHub Contact & Feedback

Cholangitis (primary sclerosing, PSC)

DOID EFO MESH SNOMED PheWeb

K11_CHOLANGI

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Endpoint definition

↥
FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K83.0
Hospital discharge: ICD-9 5761
Hospital discharge: ICD-8 5750[4-5]
Cause of death: ICD-10 K83.0
Cause of death: ICD-9 5761
Cause of death: ICD-8 5750[4-5]

2 out of 7 registries used, show all original rules.

1764

diagram downward connector

Check minimum number of events None

1764

diagram downward connector

Include endpoints None

1764

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

1715

diagram downward connector
K11_CHOLANGI

Control definitions

Control exclude K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K83
Name in latin Cholangitis

Similar endpoints

↥

List of similar endpoints to Cholangitis (primary sclerosing, PSC) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 1715 816 899
Unadjusted prevalence (%) 0.45 0.39 0.54
Mean age at first event (years) 58.35 55.83 60.63

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.77 [1.49, 9.53] 5.0e-3 361
15 years 0.01 1.36 [0.72, 2.56] 3.5e-1 85
5 years 0.01 4.55 [3.07, 6.73] 3.6e-14 104
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: K11_CHOLANGI – Cholangitis (primary sclerosing, PSC)
GWS hits:

Survival analyses between endpoints

↥

Plot

before Cholangitis (primary sclerosing, PSC)
after Cholangitis (primary sclerosing, PSC)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cholangitis (primary sclerosing, PSC)

↥