ILD-related respiratory insufficiency

ILD_INSUFFICIENCY

respiratory failure: The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. [NCIT:C26872]

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

ILD_ENDPOINTS

4337

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

748

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Remove individuals based on genotype QC

722

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ILD_INSUFFICIENCY

Control definitions

Control conditions not ILD_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 722 251 471
Unadjusted prevalence (%) 0.19 0.12 0.28
Mean age at first event (years) 70.19 67.51 71.63

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ILD_INSUFFICIENCY – ILD-related respiratory insufficiency
GWS hits: 3

Survival analyses between endpoints

Plot

before ILD-related respiratory insufficiency
after ILD-related respiratory insufficiency

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Drugs most likely to be purchased after ILD-related respiratory insufficiency

Endpoint not on priority list, no data to show.