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Interstitial lung disease

DOID EFO MESH SNOMED PheWeb

ILD

interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J84
Hospital discharge: ICD-9 515|516
Hospital discharge: ICD-8 48499|51701
Cause of death: ICD-10 J84
Cause of death: ICD-9 515|516
Cause of death: ICD-8 48499|51701

2 out of 7 registries used, show all original rules.

4337

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Check minimum number of events None

4337

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Include endpoints None

4337

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Remove individuals based on genotype QC

4213

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ILD

Control definitions

Control exclude ILD_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF6
Parent code in ICD-10 J80-J84
Name in latin Alii morbi interstitiales pulmonum

Similar endpoints

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List of similar endpoints to Interstitial lung disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 4213 1646 2567
Unadjusted prevalence (%) 1.12 0.78 1.54
Mean age at first event (years) 66.01 63.19 67.81

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 6.81 [5.16, 8.99] 9.5e-42 1153
15 years 0.02 2.40 [1.95, 2.96] 2.7e-16 319
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ILD – Interstitial lung disease
GWS hits: 13

Survival analyses between endpoints

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Plot

before Interstitial lung disease
after Interstitial lung disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Interstitial lung disease

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Endpoint not on priority list, no data to show.