Vascular syndromes of brain in cerebrovascular disorders

I9_VASCSYND

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G46*
Cause of death: ICD-10 G46*

2 out of 7 registries used, show all original rules.

1217

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Check minimum number of events None

1217

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Include endpoints None

1217

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Remove individuals based on genotype QC

1180

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I9_VASCSYND

Control definitions

Control exclude F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1180 477 703
Unadjusted prevalence (%) 0.31 0.23 0.42
Mean age at first event (years) 66.92 65.66 67.77

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.79 [1.58, 4.91] 3.8e-4 321
15 years 0.01 1.52 [0.94, 2.44] 8.6e-2 131
5 years 0.00 3.36 [2.30, 4.90] 3.6e-10 109
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_VASCSYND – Vascular syndromes of brain in cerebrovascular disorders
GWS hits:

Survival analyses between endpoints

Plot

before Vascular syndromes of brain in cerebrovascular disorders
after Vascular syndromes of brain in cerebrovascular disorders

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Drugs most likely to be purchased after Vascular syndromes of brain in cerebrovascular disorders

Endpoint not on priority list, no data to show.