obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F00-F09
Hospital discharge: ICD-9 290|3310|4378A
Hospital discharge: ICD-8 290
Cause of death: ICD-10 F00-F09
Cause of death: ICD-9 290|3310|4378A
Cause of death: ICD-8 290
KELA reimbursements: KELA codes 307
Medicine purchases: ATC N06D

4 out of 7 registries used, show all original rules.


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Check minimum number of events

Min. number of events 3


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Include endpoints


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Remove individuals based on genotype QC


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Control definitions

Control exclude F5_ORGANIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 16499 6984 9515
Unadjusted prevalence (%) 4.38 3.31 5.72
Mean age at first event (years) 77.36 77.45 77.29


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.13 7.36 [6.52, 8.31] <1e-100 7894
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: F5_DEMENTIA – Dementia
GWS hits: 15

Survival analyses between endpoints


before Dementia
after Dementia

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