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Disorders of sclera, cornea, iris and ciliary body

DOID EFO MESH SNOMED PheWeb

H7_SCLERACORNEA

corneal neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent corneal stroma. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as trachoma, viral interstitial keratitis, microbial keratoconjunctivitis, and the immune response elicited by corneal transplantation.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H15-H22, H22.0*B96.80
Cause of death: ICD-10 H15-H22, H22.0*B96.80

2 out of 7 registries used, show all original rules.

19401

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Check minimum number of events None

19401

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Include endpoints

20195

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Remove individuals based on genotype QC

19463

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H7_SCLERACORNEA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 19463 10945 8518
Unadjusted prevalence (%) 5.16 5.19 5.12
Mean age at first event (years) 49.93 49.01 51.12

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.14 [1.77, 2.58] 2.2e-15 1466
15 years 0.01 1.41 [1.20, 1.65] 3.8e-5 660
5 years 0.00 2.62 [2.23, 3.06] 9.3e-33 421
1 year 0.00 4.06 [3.26, 5.07] 1.2e-35 129

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_SCLERACORNEA – Disorders of sclera, cornea, iris and ciliary body
GWS hits: 10

Survival analyses between endpoints

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Plot

before Disorders of sclera, cornea, iris and ciliary body
after Disorders of sclera, cornea, iris and ciliary body

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Disorders of sclera, cornea, iris and ciliary body

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Endpoint not on priority list, no data to show.