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Other and unspecified corneal deformities and disorders

DOID EFO MESH SNOMED PheWeb

H7_CORNEALNAS

corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H18.7, H18.8, H18.9
Hospital discharge: ICD-9 371[7-9]
Hospital discharge: ICD-8 37860
Cause of death: ICD-10 H18.7, H18.8, H18.9
Cause of death: ICD-9 371[7-9]
Cause of death: ICD-8 37860

2 out of 7 registries used, show all original rules.

860

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Check minimum number of events None

860

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Include endpoints None

860

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Remove individuals based on genotype QC

832

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H7_CORNEALNAS

Control definitions

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6

Summary Statistics

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Key figures

All Female Male
Number of individuals 832 496 336
Unadjusted prevalence (%) 0.22 0.24 0.20
Mean age at first event (years) 50.52 49.68 51.76

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.20 [0.90, 5.37] 8.4e-2 50
15 years 0.01 0.90 [0.33, 2.46] 8.4e-1 17
5 years 0.00 3.44 [1.57, 7.56] 2.1e-3 18
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_CORNEALNAS – Other and unspecified corneal deformities and disorders
GWS hits: 5

Survival analyses between endpoints

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Plot

before Other and unspecified corneal deformities and disorders
after Other and unspecified corneal deformities and disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and unspecified corneal deformities and disorders

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Endpoint not on priority list, no data to show.