Keratoconus

DOID MESH PheWeb

H7_CORNEALDEFORM

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H18.6

Hospital discharge: ICD-9 3716

Hospital discharge: ICD-8 37103

Cause of death: ICD-10 H18.6

Cause of death: ICD-9 3716

Cause of death: ICD-8 37103

2 out of 7 registries used, show all original rules.

656

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Check minimum number of events None

656

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Include endpoints None

656

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Remove individuals based on genotype QC

625

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H7_CORNEALDEFORM

Control definitions

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H18

Name in latin Keratoconus

NAME	H7_CORNEALDEFORM
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H186
HD_ICD_9	3716
HD_ICD_8	37103
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H186
COD_ICD_9	3716
COD_ICD_8	37103
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Keratoconus based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	625	267	358
Unadjusted prevalence (%)	0.17	0.13	0.22
Mean age at first event (years)	43.45	45.67	41.80

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.13	8.95 [4.56, 17.59]	2.0e-10	23
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_CORNEALDEFORM – Keratoconus
GWS hits: 3

Survival analyses between endpoints

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Plot

before Keratoconus
after Keratoconus

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Table

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Drugs most likely to be purchased after Keratoconus

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Endpoint not on priority list, no data to show.