Keratoconus

H7_CORNEALDEFORM

No definition available.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H18.6
Hospital discharge: ICD-9 3716
Hospital discharge: ICD-8 37103
Cause of death: ICD-10 H18.6
Cause of death: ICD-9 3716
Cause of death: ICD-8 37103

2 out of 7 registries used, show all original rules.

656

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Check minimum number of events None

656

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Include endpoints None

656

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Remove individuals based on genotype QC

625

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H7_CORNEALDEFORM

Control definitions

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H18
Name in latin Keratoconus

Summary Statistics

Key figures

All Female Male
Number of individuals 625 267 358
Unadjusted prevalence (%) 0.17 0.13 0.22
Mean age at first event (years) 43.45 45.67 41.80

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.13 8.95 [4.56, 17.59] 2.0e-10 23
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_CORNEALDEFORM – Keratoconus
GWS hits: 3

Survival analyses between endpoints

Plot

before Keratoconus
after Keratoconus

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Drugs most likely to be purchased after Keratoconus

Endpoint not on priority list, no data to show.