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Generalized epilepsy

DOID EFO MESH SNOMED PheWeb

GE

generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G40.3
Hospital discharge: ICD-9 345[0-3]
Hospital discharge: ICD-8 34519
Hospital discharge: excluded ICD-8 34511
Cause of death: ICD-10 G40.3
Cause of death: ICD-9 345[0-3]
Cause of death: ICD-8 34519
Cause of death: excluded ICD-8 34511

2 out of 7 registries used, show all original rules.

1350

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Check minimum number of events None

1350

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Include endpoints None

1350

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Remove individuals based on genotype QC

1298

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GE

Control definitions

Control exclude G6_EPLEPSY

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1298 783 515
Unadjusted prevalence (%) 0.34 0.37 0.31
Mean age at first event (years) 31.12 28.92 34.46

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.55 [2.90, 7.13] 4.3e-11 133
15 years 0.02 3.10 [2.16, 4.46] 9.9e-10 58
5 years 0.00 4.38 [2.89, 6.65] 3.5e-12 26
1 year 0.00 9.32 [5.06, 17.17] 7.9e-13 12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: GE – Generalized epilepsy
GWS hits:

Survival analyses between endpoints

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Plot

before Generalized epilepsy
after Generalized epilepsy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Generalized epilepsy

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Endpoint not on priority list, no data to show.