Systemic atrophies primarily affecting the central nervous system

DOID MESH PheWeb

G6_NEUATR

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G10-G13

Cause of death: ICD-10 G10-G13

2 out of 7 registries used, show all original rules.

967

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Check minimum number of events None

967

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Include endpoints

G6_INFAMUSC

G6_ALS

G6_SPINAMUSCOTH

1122

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Remove individuals based on genotype QC

1092

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G6_NEUATR

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	G6_NEUATR
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	G6_HUNTINGTON\|G6_HERATAXIA\|G6_INFAMUSC\|G6_OTHINMUSC\|G6_ALS\|G6_SPINAMUSCOTH\|G6_POSTPOLIO
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G1
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G1
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Systemic atrophies primarily affecting the central nervous system based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1092	451	641
Unadjusted prevalence (%)	0.29	0.21	0.39
Mean age at first event (years)	57.97	54.71	60.27

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.10 [1.38, 6.98]	6.2e-3	343
15 years	0.01	1.32 [0.72, 2.44]	3.7e-1	88
5 years	0.01	4.99 [3.22, 7.73]	6.1e-13	105
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_NEUATR – Systemic atrophies primarily affecting the central nervous system
GWS hits: 7

Survival analyses between endpoints

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Plot

before Systemic atrophies primarily affecting the central nervous system
after Systemic atrophies primarily affecting the central nervous system

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Table

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Drugs most likely to be purchased after Systemic atrophies primarily affecting the central nervous system

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Endpoint not on priority list, no data to show.