≡ Risteys
R9

Documentation Changelog GitHub Contact & Feedback

Postpolio syndrome

DOID EFO MESH SNOMED PheWeb

G6_POSTPOLIO

postpoliomyelitis syndrome: Postpoliomyelitis syndrome (PPS) is a neurologic disorder characterized by the development of new neuromuscular symptoms such as progressive muscular weakness or abnormal muscle fatigability occurring in survivors of the acute paralytic form of poliomyelitis (see this term), 15-40 years after recovery from the disease, and that is unexplained by other medical causes. Other manifestations that can occur gradually include generalized fatigue, muscle atrophy, muscle and joint pain, intolerance to cold, and difficulties sleeping, swallowing or breathing.

Endpoint definition

↥
FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G14
Hospital discharge: ICD-9 138
Hospital discharge: ICD-8 4499
Cause of death: ICD-10 G14
Cause of death: ICD-9 138
Cause of death: ICD-8 4499

2 out of 7 registries used, show all original rules.

62

diagram downward connector

Check minimum number of events None

62

diagram downward connector

Include endpoints None

62

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

58

diagram downward connector
G6_POSTPOLIO

Control definitions

Control exclude G6_NEUATR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Not enough data for upset plot.

Or the full data table

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 58 33 25
Unadjusted prevalence (%) 0.02 0.02 0.02
Mean age at first event (years) 49.37 47.52 51.80

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: G6_POSTPOLIO – Postpolio syndrome
GWS hits:

Survival analyses between endpoints

↥

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Postpolio syndrome

↥

Endpoint not on priority list, no data to show.