migraine disorder: A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G43
Hospital discharge: ICD-9 346
Hospital discharge: ICD-8 346
Hospital discharge: excluded ICD-8 34601
Cause of death: ICD-10 G43
Cause of death: ICD-9 346
Cause of death: ICD-8 346
Cause of death: excluded ICD-8 34601

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints


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Remove individuals based on genotype QC


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Control definitions

Control exclude G6_EPIPAROX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47
Name in latin Hemicrania

Summary Statistics

Key figures

All Female Male
Number of individuals 18477 15262 3215
Unadjusted prevalence (%) 4.90 7.24 1.93
Mean age at first event (years) 40.59 40.28 42.04


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.31 [1.00, 1.72] 4.7e-2 369
15 years 0.01 1.04 [0.80, 1.35] 7.7e-1 192
5 years 0.00 1.14 [0.82, 1.59] 4.3e-1 57
1 year 0.00 1.95 [1.17, 3.28] 1.1e-2 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: G6_MIGRAINE – Migraine
GWS hits: 2

Survival analyses between endpoints


before Migraine
after Migraine

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