Vascular dementia

F5_VASCDEM

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F01

Hospital discharge: ICD-9 4378

Cause of death: ICD-10 F01

Cause of death: ICD-9 4378

2 out of 7 registries used, show all original rules.

2417

Check minimum number of events None

2417

Include endpoints None

2417

Remove individuals based on genotype QC

2335

F5_VASCDEM

Control definitions

Control exclude F5_DEMENTIA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 F00-F03

Name in latin Dementia vascularis

NAME	F5_VASCDEM
CONTROL_EXCLUDE	F5_DEMENTIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F01
HD_ICD_9	4378
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F01
COD_ICD_9	4378
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Vascular dementia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2335	778	1557
Unadjusted prevalence (%)	0.62	0.37	0.94
Mean age at first event (years)	79.02	80.90	78.08

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.17	11.13 [9.73, 12.73]	<1e-100	1474
15 years	0.01	2.08 [1.79, 2.41]	1.5e-21	251
5 years	0.01	6.62 [5.73, 7.66]	<1e-100	570
1 year	0.00	23.54 [20.36, 27.22]	<1e-100	645

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_VASCDEM – Vascular dementia
GWS hits: 2

Survival analyses between endpoints

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Plot

before Vascular dementia
after Vascular dementia

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Table

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Drugs most likely to be purchased after Vascular dementia

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≡ Risteys

R9

R8

R7

R6

R5

R4

R3

Vascular dementia

Endpoint definition

All original rules

Upset plot

Case counts by code for Vascular dementia (F5_VASCDEM)

Similar endpoints

Summary Statistics

Key figures

Mortality

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Authentication required

Survival analyses between endpoints

Plot

Table

Drugs most likely to be purchased after Vascular dementia