Primary ovarian failure

DOID EFO MESH SNOMED PheWeb

E4_OVARFAIL

primary ovarian insufficiency: Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule

Sex only females

219462

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Check conditions None

219462

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E28.3

Hospital discharge: ICD-9 2563

Hospital discharge: ICD-8 2561

Cause of death: ICD-10 E28.3

Cause of death: ICD-9 2563

Cause of death: ICD-8 2561

KELA reimbursements: KELA codes ANY

KELA reimbursements: ICD-10 E28.3

3 out of 7 registries used, show all original rules.

499

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Check minimum number of events None

499

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Include endpoints None

499

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Remove individuals based on genotype QC

469

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E4_OVARFAIL

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E28

Name in latin Insufficientia ovariorum primaria

NAME	E4_OVARFAIL
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E283
HD_ICD_9	2563
HD_ICD_8	2561
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E283
COD_ICD_9	2563
COD_ICD_8	2561
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	ANY
KELA_REIMB_ICD	E283
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Primary ovarian failure based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	469	469	-
Unadjusted prevalence (%)	0.12	0.22	-
Mean age at first event (years)	35.80	35.80	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	3.38 [1.48, 7.68]	3.7e-3	18
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_OVARFAIL – Primary ovarian failure
GWS hits:

Survival analyses between endpoints

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Plot

before Primary ovarian failure
after Primary ovarian failure

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Table

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Drugs most likely to be purchased after Primary ovarian failure

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Endpoint not on priority list, no data to show.