Mixed hyperlipidaemia

E4_HYPERLIPMIX

obsolete_familial combined hyperlipidemia: ['A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.']

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E78.2
Hospital discharge: ICD-9 2722
Cause of death: ICD-10 E78.2
Cause of death: ICD-9 2722

2 out of 7 registries used, show all original rules.

1122

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Check minimum number of events None

1122

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Include endpoints None

1122

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Remove individuals based on genotype QC

1084

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E4_HYPERLIPMIX

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E78

Summary Statistics

Key figures

All Female Male
Number of individuals 1084 377 707
Unadjusted prevalence (%) 0.29 0.18 0.43
Mean age at first event (years) 55.52 56.23 55.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.59 [1.63, 4.12] 5.3e-5 203
15 years 0.01 1.75 [1.14, 2.66] 9.7e-3 100
5 years 0.00 2.88 [1.92, 4.31] 2.7e-7 44
1 year 0.00 6.55 [3.82, 11.22] 8.0e-12 18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_HYPERLIPMIX – Mixed hyperlipidaemia
GWS hits: 5

Survival analyses between endpoints

Plot

before Mixed hyperlipidaemia
after Mixed hyperlipidaemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed hyperlipidaemia

Endpoint not on priority list, no data to show.