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Mixed hyperlipidaemia

DOID EFO MESH PheWeb

E4_HYPERLIPMIX

obsolete_familial combined hyperlipidemia: ['A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.']

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E78.2
Hospital discharge: ICD-9 2722
Cause of death: ICD-10 E78.2
Cause of death: ICD-9 2722

2 out of 7 registries used, show all original rules.

1122

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Check minimum number of events None

1122

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Include endpoints None

1122

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Remove individuals based on genotype QC

1084

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E4_HYPERLIPMIX

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E78

Summary Statistics

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Key figures

All Female Male
Number of individuals 1084 377 707
Unadjusted prevalence (%) 0.29 0.18 0.43
Mean age at first event (years) 55.52 56.23 55.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.59 [1.63, 4.12] 5.3e-5 203
15 years 0.01 1.75 [1.14, 2.66] 9.7e-3 100
5 years 0.00 2.88 [1.92, 4.31] 2.7e-7 44
1 year 0.00 6.55 [3.82, 11.22] 8.0e-12 18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERLIPMIX – Mixed hyperlipidaemia
GWS hits: 5

Survival analyses between endpoints

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Plot

before Mixed hyperlipidaemia
after Mixed hyperlipidaemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed hyperlipidaemia

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Endpoint not on priority list, no data to show.