Adrenocortical insufficiency


No definition available.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E27.1, E27.2, E27.3#, E27.4
Hospital discharge: ICD-9 2554
Hospital discharge: ICD-8 2551
Cause of death: ICD-10 E27.1, E27.2, E27.3#, E27.4
Cause of death: ICD-9 2554
Cause of death: ICD-8 2551
KELA reimbursements: KELA codes 105

3 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 923 617 306
Unadjusted prevalence (%) 0.24 0.29 0.18
Mean age at first event (years) 50.88 49.36 53.94


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.67 [0.47, 5.93] 4.3e-1 107
15 years 0.01 0.90 [0.33, 2.42] 8.3e-1 34
5 years 0.00 3.50 [1.59, 7.70] 1.9e-3 37
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_ADDISON – Adrenocortical insufficiency
GWS hits: 1

Survival analyses between endpoints


before Adrenocortical insufficiency
after Adrenocortical insufficiency

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Drugs most likely to be purchased after Adrenocortical insufficiency

Endpoint not on priority list, no data to show.