Adrenocortical insufficiency

DOID MESH PheWeb

E4_ADDISON

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E27.1, E27.2, E27.3#, E27.4

Hospital discharge: ICD-9 2554

Hospital discharge: ICD-8 2551

Cause of death: ICD-10 E27.1, E27.2, E27.3#, E27.4

Cause of death: ICD-9 2554

Cause of death: ICD-8 2551

KELA reimbursements: KELA codes 105

3 out of 7 registries used, show all original rules.

951

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Check minimum number of events None

951

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Include endpoints None

951

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Remove individuals based on genotype QC

923

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E4_ADDISON

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

NAME	E4_ADDISON
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E27[1-4]
HD_ICD_9	2554
HD_ICD_8	2551
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E27[1-4]
COD_ICD_9	2554
COD_ICD_8	2551
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	105
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Adrenocortical insufficiency based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Drug-induced adrenocortical insufficiency

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	923	617	306
Unadjusted prevalence (%)	0.24	0.29	0.18
Mean age at first event (years)	50.88	49.36	53.94

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.67 [0.47, 5.93]	4.3e-1	107
15 years	0.01	0.90 [0.33, 2.42]	8.3e-1	34
5 years	0.00	3.50 [1.59, 7.70]	1.9e-3	37
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_ADDISON – Adrenocortical insufficiency
GWS hits: 1

Survival analyses between endpoints

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Plot

before Adrenocortical insufficiency
after Adrenocortical insufficiency

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Table

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Drugs most likely to be purchased after Adrenocortical insufficiency

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Endpoint not on priority list, no data to show.