Drug-induced adrenocortical insufficiency

DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E27.3#

1 out of 7 registries used, show all original rules.

417

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Check minimum number of events None

417

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Include endpoints None

417

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Remove individuals based on genotype QC

403

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DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF5

NAME	DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E273
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Drug-induced adrenocortical insufficiency based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	403	280	123
Unadjusted prevalence (%)	0.11	0.13	0.07
Mean age at first event (years)	56.04	54.14	60.38

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.66 [0.54, 5.13]	3.8e-1	25
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY – Drug-induced adrenocortical insufficiency
GWS hits:

Survival analyses between endpoints

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Plot

before Drug-induced adrenocortical insufficiency
after Drug-induced adrenocortical insufficiency

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Drug-induced adrenocortical insufficiency

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Endpoint not on priority list, no data to show.