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Secondary polycythaemia

DOID EFO MESH PheWeb

D3_SCNDPOLYCYTHAEMIA

polycythemia: Abnormally high mass or concentration of red blood cells in the blood, either due to an increase in erythropoiesis or a decrease in plasma volume.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D75.1
Hospital discharge: ICD-9 2890
Hospital discharge: ICD-8 28900
Cause of death: ICD-10 D75.1
Cause of death: ICD-9 2890
Cause of death: ICD-8 28900

2 out of 7 registries used, show all original rules.

626

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Check minimum number of events None

626

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Include endpoints None

626

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Remove individuals based on genotype QC

608

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D3_SCNDPOLYCYTHAEMIA

Control definitions

Control exclude D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D75
Name in latin Polycythaemia secundaria

Similar endpoints

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List of similar endpoints to Secondary polycythaemia based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 608 207 401
Unadjusted prevalence (%) 0.16 0.10 0.24
Mean age at first event (years) 56.70 56.22 56.94

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.56 [3.14, 6.62] 1.4e-15 89
15 years 0.02 2.54 [1.72, 3.75] 3.1e-6 44
5 years 0.00 3.05 [1.90, 4.89] 3.6e-6 28
1 year 0.00 6.61 [3.42, 12.75] 1.9e-8 12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_SCNDPOLYCYTHAEMIA – Secondary polycythaemia
GWS hits:

Survival analyses between endpoints

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Plot

before Secondary polycythaemia
after Secondary polycythaemia

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Drugs most likely to be purchased after Secondary polycythaemia

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Endpoint not on priority list, no data to show.