Hyperimmunoglobulin E [IgE] syndrome

D3_HYPERIGESDR

obsolete_Job's syndrome: ['Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.']

Endpoint definition

FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D82.4
Cause of death: ICD-10 D82.4

2 out of 7 registries used, show all original rules.

18

diagram downward connector

Check minimum number of events None

18

diagram downward connector

Include endpoints None

18

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

17

diagram downward connector
D3_HYPERIGESDR

Control definitions

Control exclude D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D82
Name in latin Syndroma hyperimmunoglobulini E (IgE)

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 17 11 6
Unadjusted prevalence (%) 0.00 0.01 0.00
Mean age at first event (years) 40.21 35.77 48.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_HYPERIGESDR – Hyperimmunoglobulin E [IgE] syndrome
GWS hits:

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Hyperimmunoglobulin E [IgE] syndrome

Endpoint not on priority list, no data to show.