Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function

D3_CVID_TCELL

obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D83.1
Hospital discharge: ICD-9 2791X
Cause of death: ICD-10 D83.1
Cause of death: ICD-9 2791X

2 out of 7 registries used, show all original rules.

37

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Check minimum number of events None

37

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Include endpoints None

37

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Remove individuals based on genotype QC

36

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D3_CVID_TCELL

Control definitions

Control exclude D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D83
Name in latin Deficientia immunalis variabilis communis praecipue cum abnormalitatibus cellularum T immunoregulatoriarum

Summary Statistics

Key figures

All Female Male
Number of individuals 36 25 11
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 54.63 52.50 59.47

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_CVID_TCELL – Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function
GWS hits:

Survival analyses between endpoints

Plot

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Drugs most likely to be purchased after Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function

Endpoint not on priority list, no data to show.