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Asthma-related infections

DOID EFO MESH SNOMED PheWeb

ASTHMA_INFECTIONS

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

J10_ASTHMA

43630

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

22692

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Remove individuals based on genotype QC

21927

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ASTHMA_INFECTIONS

Control definitions

Control exclude ASTHMA_HOSPITAL_INFECTIONS
Control conditions not J10_ASTHMA

Extra metadata

First used in FinnGen datafreeze DF2

No data for upset plot.

No data for upset table.

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 21927 12422 9505
Unadjusted prevalence (%) 5.81 5.89 5.72
Mean age at first event (years) 44.46 43.49 45.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.87 [2.31, 3.55] 6.5e-22 3262
15 years 0.01 1.58 [1.35, 1.86] 2.2e-8 1213
5 years 0.00 3.08 [2.68, 3.54] 3.1e-57 892
1 year 0.00 11.94 [10.36, 13.76] <1e-100 723

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ASTHMA_INFECTIONS – Asthma-related infections
GWS hits: 21

Survival analyses between endpoints

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Plot

before Asthma-related infections
after Asthma-related infections

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Asthma-related infections

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Endpoint not on priority list, no data to show.