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Ulcerative colitis, NAS

DOID EFO MESH SNOMED PheWeb

ULCERNAS

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K51.9
Cause of death: ICD-10 K51.9

2 out of 7 registries used, show all original rules.

4682

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Check minimum number of events None

4682

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Include endpoints None

4682

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Remove individuals based on genotype QC

4527

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ULCERNAS

Control definitions

Control exclude K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K51
Name in latin Colitis ulcerosa non specificata

Summary Statistics

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Key figures

All Female Male
Number of individuals 4527 2426 2101
Unadjusted prevalence (%) 1.20 1.15 1.26
Mean age at first event (years) 46.13 44.04 48.55

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.28 [1.60, 3.25] 4.4e-6 318
15 years 0.01 1.21 [0.82, 1.79] 3.3e-1 132
5 years 0.00 2.47 [1.76, 3.48] 1.9e-7 85
1 year 0.00 8.56 [5.97, 12.29] 2.3e-31 58

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ULCERNAS – Ulcerative colitis, NAS
GWS hits: 18

Survival analyses between endpoints

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Plot

before Ulcerative colitis, NAS
after Ulcerative colitis, NAS

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ulcerative colitis, NAS

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Endpoint not on priority list, no data to show.