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Ulcerative ileocolitis

DOID EFO MESH SNOMED PheWeb

ULCERILEO

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K51.1
Cause of death: ICD-10 K51.1

2 out of 7 registries used, show all original rules.

1290

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Check minimum number of events None

1290

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Include endpoints None

1290

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Remove individuals based on genotype QC

1261

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ULCERILEO

Control definitions

Control exclude K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K51
Name in latin Ileocolitis ulcerosa [chronica]

Summary Statistics

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Key figures

All Female Male
Number of individuals 1261 663 598
Unadjusted prevalence (%) 0.33 0.31 0.36
Mean age at first event (years) 42.85 40.43 45.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.05 [2.40, 6.81] 1.4e-7 61
15 years 0.01 2.13 [1.27, 3.56] 4.1e-3 27
5 years 0.00 3.35 [1.86, 6.04] 5.4e-5 17
1 year 0.00 10.05 [4.90, 20.60] 3.0e-10 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ULCERILEO – Ulcerative ileocolitis
GWS hits: 2

Survival analyses between endpoints

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Plot

before Ulcerative ileocolitis
after Ulcerative ileocolitis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ulcerative ileocolitis

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Endpoint not on priority list, no data to show.