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Type 2 diabetes, wide definition

DOID EFO MESH SNOMED PheWeb

T2D_WIDE

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

not PANCREATITIS

386024

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E11
Hospital discharge: ICD-9 250.A
Cause of death: ICD-10 E11
Cause of death: ICD-9 250.A

2 out of 7 registries used, show all original rules.

40055

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Check minimum number of events None

40055

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Include endpoints None

40055

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Remove individuals based on genotype QC

38657

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T2D_WIDE

Control definitions

Control exclude T2D
Control conditions not PANCREATITIS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Summary Statistics

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Key figures

All Female Male
Number of individuals 38657 15796 22861
Unadjusted prevalence (%) 10.25 7.49 13.75
Mean age at first event (years) 62.87 61.86 63.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.03 [3.46, 4.69] 2.2e-72 9182
15 years 0.01 2.27 [2.01, 2.55] 7.2e-42 3668
5 years 0.00 4.06 [3.75, 4.40] <1e-100 2743
1 year 0.00 13.34 [12.06, 14.75] <1e-100 1934

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T2D_WIDE – Type 2 diabetes, wide definition
GWS hits: 143

Survival analyses between endpoints

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Plot

before Type 2 diabetes, wide definition
after Type 2 diabetes, wide definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 2 diabetes, wide definition

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Endpoint not on priority list, no data to show.