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Type 1 diabetes, wide definition

DOID EFO MESH SNOMED PheWeb

T1D_WIDE

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

9209

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Remove individuals based on genotype QC

8967

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T1D_WIDE

Control definitions

Control exclude DIABETES_FG

Extra metadata

First used in FinnGen datafreeze DF2

No data for upset plot.

No data for upset table.

Similar endpoints

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List of similar endpoints to Type 1 diabetes, wide definition based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 8967 4320 4647
Unadjusted prevalence (%) 2.38 2.05 2.79
Mean age at first event (years) 28.52 26.38 30.51

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.73 [1.95, 3.80] 3.5e-9 1136
15 years 0.01 2.09 [1.63, 2.67] 5.8e-9 516
5 years 0.00 2.42 [1.90, 3.08] 5.4e-13 148
1 year 0.00 2.68 [1.78, 4.02] 2.0e-6 29

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T1D_WIDE – Type 1 diabetes, wide definition
GWS hits: 48

Survival analyses between endpoints

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Plot

before Type 1 diabetes, wide definition
after Type 1 diabetes, wide definition

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Drugs most likely to be purchased after Type 1 diabetes, wide definition

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Endpoint not on priority list, no data to show.