Systemic sclerosis,strict definition

SYSTSCLE_STRICT

scleroderma: Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc) (see these terms).

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

SYSTSCLE_ICD10

625

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M34

1 out of 7 registries used, show all original rules.

201

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Check minimum number of events None

201

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Include endpoints None

201

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Remove individuals based on genotype QC

194

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SYSTSCLE_STRICT

Control definitions

Control conditions not SYSTSCLE_ICD10

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 194 171 23
Unadjusted prevalence (%) 0.05 0.08 0.01
Mean age at first event (years) 54.09 53.90 55.51

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: SYSTSCLE_STRICT – Systemic sclerosis,strict definition
GWS hits: 1

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Systemic sclerosis,strict definition

Endpoint not on priority list, no data to show.