Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

N14_DRUGSANDHEAVYMETAL

acute kidney tubular necrosis: Acute renal failure caused by the cell death of the renal tubules. Causes include nephrotoxins, cytotoxic drugs, and antibiotics.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 N14

Cause of death: ICD-10 N14

2 out of 7 registries used, show all original rules.

Check minimum number of events None

Include endpoints None

Remove individuals based on genotype QC

N14_DRUGSANDHEAVYMETAL

Control definitions

Control exclude N14_RENALTUB

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 N10-N16

Name in latin Condiciones tubulo-interstitiales et tubulares ex medicamentis et metallis gravibus

NAME	N14_DRUGSANDHEAVYMETAL
CONTROL_EXCLUDE	N14_RENALTUB
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	N14
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	N14
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	77	31	46
Unadjusted prevalence (%)	0.02	0.01	0.03
Mean age at first event (years)	54.19	55.95	53.01

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: N14_DRUGSANDHEAVYMETAL – Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
GWS hits:

Survival analyses between endpoints

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Plot

before Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
after Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

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Table

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Drugs most likely to be purchased after Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

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Endpoint not on priority list, no data to show.

≡ Risteys

R9

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R4

R3