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Giant cell arteritis

DOID EFO MESH SNOMED PheWeb

M13_GIANTCELL

temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M31.5, M31.6
Hospital discharge: ICD-9 4465
Cause of death: ICD-10 M31.5, M31.6
Cause of death: ICD-9 4465

2 out of 7 registries used, show all original rules.

1022

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Check minimum number of events None

1022

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Include endpoints

1022

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Remove individuals based on genotype QC

996

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M13_GIANTCELL

Control definitions

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 996 597 399
Unadjusted prevalence (%) 0.26 0.28 0.24
Mean age at first event (years) 68.36 67.69 69.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.89 [1.89, 4.42] 1.1e-6 161
15 years 0.01 1.20 [0.76, 1.90] 4.4e-1 62
5 years 0.00 2.53 [1.66, 3.85] 1.4e-5 58
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_GIANTCELL – Giant cell arteritis
GWS hits:

Survival analyses between endpoints

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Plot

before Giant cell arteritis
after Giant cell arteritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Giant cell arteritis

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