Allergic urticaria

L12_URTICA_ALLERG

allergic urticaria: commonly referred to as hives, is a kind of skin rash notable for pale red, raised, itchy bumps. Hives may cause a burning or stinging sensation. Histamine and other proinflammatory substances are released from mast cells in the skin and tissues in response to the binding of allergen-bound IgE antibodies to high-affinity cell surface receptors. Basophils and other inflammatory cells are also seen to release histamine and other mediators, and are thought to play an important role, especially in chronic urticarial diseases.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L50.0
Hospital discharge: ICD-9 7080
Cause of death: ICD-10 L50.0
Cause of death: ICD-9 7080

2 out of 7 registries used, show all original rules.

2488

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Check minimum number of events None

2488

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Include endpoints None

2488

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Remove individuals based on genotype QC

2386

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L12_URTICA_ALLERG

Control definitions

Control exclude L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L50
Name in latin Urticaria allergica

Summary Statistics

Key figures

All Female Male
Number of individuals 2386 1695 691
Unadjusted prevalence (%) 0.63 0.80 0.42
Mean age at first event (years) 42.11 41.25 44.21

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.34 [0.44, 4.09] 6.1e-1 134
15 years 0.01 0.99 [0.42, 2.29] 9.7e-1 57
5 years 0.00 2.42 [1.29, 4.53] 5.9e-3 39
1 year 0.00 4.11 [1.92, 8.80] 2.8e-4 12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_URTICA_ALLERG – Allergic urticaria
GWS hits: 1

Survival analyses between endpoints

Plot

before Allergic urticaria
after Allergic urticaria

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Drugs most likely to be purchased after Allergic urticaria

Endpoint not on priority list, no data to show.