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Atrophic disorders of skin

DOID EFO MESH SNOMED PheWeb

L12_ATROPHICSKIN

skin atrophy: The structural changes and the signs and symptoms of chronologically aged skinand those of corticosteroid induced chronicatrophyof theskinare partially very similar.Thinningof epidermis and laxity as well as dryness, purpura and echymoses occur in both conditions.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L90
Cause of death: ICD-10 L90

2 out of 7 registries used, show all original rules.

3752

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Check minimum number of events None

3752

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Include endpoints

3952

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Remove individuals based on genotype QC

3839

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L12_ATROPHICSKIN

Control definitions

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L80-L99
Name in latin Morbositates atrophicae cutis

Similar endpoints

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List of similar endpoints to Atrophic disorders of skin based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 3839 3192 647
Unadjusted prevalence (%) 1.02 1.51 0.39
Mean age at first event (years) 54.81 56.11 48.43

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.60 [1.04, 2.48] 3.3e-2 144
15 years 0.01 1.10 [0.73, 1.67] 6.5e-1 74
5 years 0.00 1.40 [0.89, 2.21] 1.5e-1 32
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_ATROPHICSKIN – Atrophic disorders of skin
GWS hits:

Survival analyses between endpoints

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Plot

before Atrophic disorders of skin
after Atrophic disorders of skin

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Drugs most likely to be purchased after Atrophic disorders of skin

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Endpoint not on priority list, no data to show.