Acute appendicitis


appendicitis: Acute inflammation of the vermiform appendix.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K35
Hospital discharge: ICD-9 540
Hospital discharge: ICD-8 540
Cause of death: ICD-10 K35
Cause of death: ICD-9 540
Cause of death: ICD-8 540

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude K11_APPENDIX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K35-K38
Name in latin Appendicitis acuta

Summary Statistics

Key figures

All Female Male
Number of individuals 28745 15576 13169
Unadjusted prevalence (%) 7.62 7.39 7.92
Mean age at first event (years) 34.78 32.85 37.05


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.17 [0.97, 1.41] 1.1e-1 1775
15 years 0.01 0.87 [0.74, 1.04] 1.3e-1 764
5 years 0.00 1.19 [1.01, 1.41] 4.3e-2 268
1 year 0.00 2.30 [1.81, 2.93] 1.1e-11 93

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: K11_APPENDACUT – Acute appendicitis
GWS hits: 15

Survival analyses between endpoints


before Acute appendicitis
after Acute appendicitis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Acute appendicitis