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Rheumatic fever without mention of heart involvement

DOID EFO MESH SNOMED PheWeb

I9_RHEUFEVWITHOUTHEART

rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I00, I00+J17.8, I00+L54.0, I02.9
Hospital discharge: ICD-9 390
Hospital discharge: ICD-8 390
Cause of death: ICD-10 I00, I00+J17.8, I00+L54.0, I02.9
Cause of death: ICD-9 390
Cause of death: ICD-8 390

2 out of 7 registries used, show all original rules.

99

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Check minimum number of events None

99

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Include endpoints None

99

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Remove individuals based on genotype QC

97

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I9_RHEUFEVWITHOUTHEART

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 97 52 45
Unadjusted prevalence (%) 0.03 0.02 0.03
Mean age at first event (years) 33.53 32.06 35.22

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_RHEUFEVWITHOUTHEART – Rheumatic fever without mention of heart involvement
GWS hits:

Survival analyses between endpoints

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Plot

before Rheumatic fever without mention of heart involvement
after Rheumatic fever without mention of heart involvement

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Rheumatic fever without mention of heart involvement

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Endpoint not on priority list, no data to show.